Nitrosamines are compounds with a nitroso group and amine bonded together. Nitrosamines are formed by the reaction of secondary amines, amides, carbamates, derivatives of urea with nitrite or other nitrogenous agents with the nitrogen in the +3 state. Nitrosamine impurities are probable human carcinogens. FDA has released this document because of In July 2018, when authorities announced a recall of angiotensin II receptor blocker (ARB) medicines, known as “sartans”, due to being a probable human carcinogen N-nitrosodimethylamine (NDMA). After that incident, Nitrosamine impurities came in limelight.